Does semaglutide contain Vitamin B12?
No, semaglutide (copyright®, Wegovy®, Rybelsus®) does not contain Vitamin B12 in its standard FDA-approved formulations. It is a GLP-1 receptor agonist developed for blood sugar control and weight management, not a vitamin supplement.
Why do some people think semaglutide includes B12?
This confusion comes from compounded versions of semaglutide. Some compounding pharmacies add Vitamin B12 to their formulations to:
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Reduce nausea and fatigue
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Improve energy and metabolism
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Support patients with low B12 levels
These additions are not part of the original FDA-approved drug, but rather an optional modification in custom formulations.
Can semaglutide cause Vitamin B12 deficiency?
Semaglutide itself does not directly deplete B12. However, long-term appetite changes, reduced food intake, or digestive effects may contribute to lower B12 levels in some patients. Symptoms like fatigue, tingling, or brain fog may indicate deficiency, which can be tested and corrected.
Should I take Vitamin B12 while on semaglutide?
Yes, many patients safely take B12 supplements alongside semaglutide, especially if they:
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Follow a vegan or vegetarian diet
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Experience low energy or neuropathy symptoms
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Have diagnosed B12 deficiency
Always check with your doctor or pharmacist before starting supplements to ensure safe and effective use.
Are compounded semaglutide + B12 injections better?
Some patients report improved energy, fewer side effects, and better tolerance when using compounded semaglutide with added B12. However, compounded versions are not FDA-approved, so their safety and consistency may vary. Always use a licensed pharmacy and consult your healthcare provider before choosing compounded medication.
Key Takeaway
Semaglutide does not naturally contain Vitamin B12. Only certain compounded formulations include it. If you’re concerned about B12 deficiency, talk with your healthcare provider about testing or supplementation.
Medical Disclaimer: This article is for educational purposes only. Always consult your doctor before starting, stopping, or combining medications and supplements.
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